Integrin Dynamics and Matrix Assembly

Fibronectin matrix assembly is a multistep, integrin-dependent process. To investigate the role of integrin dynamics in fibronectin fibrillogenesis, we dev...

Pankov，R. - 《Journal of Cell Biology》

Regulation of fibronectin receptor distribution

To determine the role of each intracellular domain of the fibronectin receptor in receptor distribution, chimeric receptors were constructed containing the...

Susan E. LaFlamme，Steven K. Akiyama and Kenneth M. Yamada - 《Journal of Cell Biology》

Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion.

Integrin-linked focal adhesion complexes provide the main sites of cell adhesion to extracellular matrix and associate with the actin cytoskeleton to contr...

NO Carragher，MC Frame - 《Trends in Cell Biology》

Integrin-ECM Interactions Regulate Cadherin-Dependent Cell Adhesion and Are Required for Convergent Extension in Xenopus

Background: Convergence extension movements are conserved tissue rearrangements implicated in multiple morphogenetic events. While many of the cell behavio...

M Marsden，DW Desimone - 《Current Biology Cb》

Cell adhesion nucleation regulated by substrate stiffness: a Monte Carlo study.

Cell adhesions are modulated by the interactions between cells and their surroundings, among which substrate stiffness plays an important role in mediating...

X Peng，J Huang，C Xiong，... - 《Journal of Biomechanics》

Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways.

Cell forces define cell morphology, alterations in which are caused by tyrosine kinase and phosphatase mutations, which implies a causal linkage. Recent st...

G Giannone，MP Sheetz - 《Trends in Cell Biology》

Neurexin-1β binding to neuroligin-1 triggers the preferential recruitment of PSD-95 versus gephyrin through tyrosine phosphorylation of neuroligin-1.

Adhesion between neurexin-1 beta (Nrx1 beta) and neuroligin- 1 (Nlg1) induces early recruitment of the postsynaptic density protein 95 (PSD-95) scaffold; h...

G Giannone，M Mondin，D Grillo-Bosch，... - 《Cell Reports》

Dynamics of β1-Integrins in Living Fibroblasts—Effect of Substratum Wettability

The dynamics of integrin receptors mobility was studied in living human fibroblasts using fluorescence-labeled β1-integrin monoclonal antibodies. Time-lap...

IZGL Altankov - 《Biophysical Journal》

The behaviour of fibroblasts migrating from chick heart explants: changes in adhesion, locomotion and growth, and in the distribution of actomyosin and fib...

Fibroblasts migrating from heart explants of chick embryos at first have a high rate of locomotion but lack focal contacts or adhesions and also lack subst...

JR Couchman，DA Rees - 《Journal of Cell Science》

Focal adhesions: structure and dynamics - ScienceDirect

Interactions of cells with the extracellular matrix are essential for the control of tissue remodelling, cell migration, and embryogenesis. At the cellextr...

P Valérie，T Jean‐Paul - 《Biology of the Cell》