The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling.
摘要：
SH2 domains are interaction modules uniquely dedicated to the recognition of phosphotyrosine sites and are embedded in proteins that couple protein-tyrosine kinases to intracellular signaling pathways. Here, we report a comprehensive bioinformatics, structural, and functional view of the human and mouse complement of SH2 domain proteins. This information delimits the set of SH2-containing effectors available for PTK signaling and will facilitate the systems-level analysis of pTyr-dependent protein-protein interactions and PTK-mediated signal transduction. The domain-based architecture of SH2-containing proteins is of more general relevance for understanding the large family of protein interaction domains and the modular organization of the majority of human proteins.
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关键词：
B-CELL DEVELOPMENT SEVERE COMBINED IMMUNODEFICIENCY TYROSINE-PHOSPHATASE SHP-2 MICE LACKING SUPPRESSOR SRC HOMOLOGY-2 DOMAIN INCREASED INSULIN SENSITIVITY GTPASE-ACTIVATING PROTEIN ACUTE MYELOID-LEUKEMIA LYN-DEFICIENT MICE ADAPTER PROTEIN
DOI：
10.1016/j.molcel.2006.06.001
被引量：
年份：
2006
Elsevier
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Elsevier
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万方医学
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