Cylodextrin Complexation Methods for Formulating Peptide Proteasome Inhibitors
申请(专利)号:
EP24170493.1;EP202400000170493;EP24170493A;EP20240170493
申请日期:
2013-05-08
公开/公告号:
EP4410374A2;EP2024004410374A2;EP4410374A2;EP4410374
公开/公告日期:
2024-08-07
申请(专利权)人:
ONYX THERAPEUTICS, INC.
被引量:
摘要:
This disclosure provides methods for formulating compositions comprising one or more peptide proteasome inhibitors and a cyclodextrin, particularly a substituted cyclodextrin. Such methods substantially increase the solubility and stability of these proteasome inhibitors and facilitate both their manufacture and administration.
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