HLA-DP-associated susceptibility to the optico-spinal form of multiple sclerosis in the Japanese
摘要：
We studied polymorphism of the HLA-DP gene in 46 patients with optico-spinal form (Asian type) multiple sclerosis (MS) showing recurrent opticomyelitis and 46 patients with Western type MS with disseminated central nervous system involvement. We previously reported a significant association between an HLA-DRB1 *1501- DRB5 * 0101 haplotype and susceptibility to Western type but not Asian type MS. In the present study, we found that the frequencies of DPAl * 0202 and DPB1 * 0501 alleles were significantly increased in patients with Asian type MS, as compared with findings in 92 healthy control subjects (91.3% vs 65.2%, P corr <0.05 and 89.1% vs 63.0%, P corr < 0.05 respectively), but not in Western type MS. Our data provide further evidence that Asian and Western type MS are distinct regarding the immunogenetic background.
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DOI：
10.1111/j.1399-0039.1998.tb02282.x
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年份：
1998
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