Sustained release matrix system using hydroxyethyl cellulose and hydroxypropyl cellulose polymer blends
申请(专利)号:
US19930156223
申请日期:
1993-11-22
公开/公告号:
US5451409A
公开/公告日期:
1995-09-19
申请(专利权)人:
RENCHER; WILLIAM F.;BABU; SURESH;MUSUNURI; SHANKAR;DAY; CHRISTOPHER H.;SCHWING; JAMES
被引量:
摘要:
The present invention is directed to a novel sustained release matrix and oral dosage form comprising a homogeneous matrix formed from a wet granulation containing an effective amount of a medicament and a polymer blend of hydroxypropyl cellulose and hydroxyethyl cellulose. The present invention also discloses a novel process for making a sustained release oral dosage form comprising wet granulating a medicament with a polymer blend of hydroxypropyl cellulose and hydroxyethyl cellulose to form a homogeneous matrix, wherein the polymer blend is provided in an amount effective to control the release of said medicament, then forming the homogenous matrix into a solid oral dosage form.
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