Sustained release matrix system using hydroxyethyl cellulose and hydroxypropyl cellulose polymer blends

阅读量:

44

申请(专利)号:

US19930156223

申请日期:

1993-11-22

公开/公告号:

US5451409A

公开/公告日期:

1995-09-19

申请(专利权)人:

RENCHER; WILLIAM F.;BABU; SURESH;MUSUNURI; SHANKAR;DAY; CHRISTOPHER H.;SCHWING; JAMES

发明人:

WF RencherS BabuS MusunuriCH DayJ Schwing

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被引量:

126

摘要:

The present invention is directed to a novel sustained release matrix and oral dosage form comprising a homogeneous matrix formed from a wet granulation containing an effective amount of a medicament and a polymer blend of hydroxypropyl cellulose and hydroxyethyl cellulose. The present invention also discloses a novel process for making a sustained release oral dosage form comprising wet granulating a medicament with a polymer blend of hydroxypropyl cellulose and hydroxyethyl cellulose to form a homogeneous matrix, wherein the polymer blend is provided in an amount effective to control the release of said medicament, then forming the homogenous matrix into a solid oral dosage form.

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