The lin-12 locus specifies cell fates in Caenorhabditis elegans.
摘要：
We describe two classes of mutations in the lin-12 locus of the nematode Caenorhabditis elegans. Ten semidominant mutations ( lin-12[d]) appear to elevate the level of lin-12 activity. Thirty-two recessive alleles ( lin-12[0]), including two amber mutations, appear to eliminate gene activity. The lin-12(d) and lin-12(0) mutations result in reciprocal homeotic transformations in the fates of defined cells in several different tissues. Gene dosage studies suggest that a high level of lin-12 activity specifies one cell fate and a low level specifies an alternative fate. Temperature-shift experiments indicate that lin-12 acts at the time cell fate is determined in wild type. We propose that lin-12 functions as a binary switch to control decisions between alternative cell fates during C. elegans development.
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关键词：
Animals Caenorhabditis Chromosome Mapping Cell Differentiation Phenotype Mutation Alleles Dosage Compensation, Genetic
DOI：
10.1016/0092-8674(83)90377-X
被引量：
年份：
1983
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