Activation of the MAP kinase pathway by the protein kinase Raf
摘要：
Both MAP kinases and the protein kinase p74 raf-1 are activated by many growth factors in a c-ras-dependent manner and by oncogenic p21 ras . We were therefore interested in determining the relationship between MAP kinases and raf. The MAP kinase ERK2 is activated by expression of oncogenically activated raf , independently of cellular ras . Overexpressed p74 raf-1 potentiates activation of ERK2 by EGF and TPA. MAP kinase kinase inactivated by phosphatase 2A treatment is phosphorylated and reactivated by incubation with p74 raf-1 immunoprecipitated from phorbol estertreated cells. We conclude that raf protein kinase is upstream of MAP kinases and is either a MAP kinase kinase kinase or a MAP kinase kinase kinase kinase.
展开
DOI：
10.1016/0092-8674(92)90361-F
被引量：
年份：
1992
Elsevier
万方医学
dx.doi.org
NCBI
Cell Press
(全网免费下载)
查看更多
Cell Press
BioMed Central
NCBI
Europe PMC
EureKaMag.com
(全网免费下载)
ResearchGate
EBSCO
uabcei.pure.elsevier.com
SAGE
emboj.embopress.org
ajprenal.physiology.org
jcs.biologists.org
molbiolcell.org
mendeley.com
readcube.com
arnetminer.org
(全网免费下载)
mysciencework.com
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
