Dealing with energy demand: the AMP-activated protein kinase.
摘要：
The AMP-activated protein kinase (AMPK) is a member of a metabolite-sensing protein kinase family that is found in all eukaryotes. AMPK activity is regulated by vigorous exercise, nutrient starvation and ischemia/hypoxia, and modulates many aspects of mammalian cell metabolism. The AMPK yeast homolog, Snf1p, plays a major role in adaption to glucose deprivation. In mammals, AMPK also has diverse roles that extend from energy metabolism through to transcriptional control.
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关键词：
Biochemistry Cell biology AMP-activated prtoein kinase snf1 protein kinase regulation phosphorylation metabolism
DOI：
DOI: 10.1016/S0968-0004(98)01340-1
被引量：
年份：
1999
Elsevier
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