Deletions below 10 megabasepairs are detected in comparative genomic hybridization by standard reference intervals
摘要：
Comparative genomic hybridization (CGH) is a widely used technique for studying chromosomal imbalances. The sensitivity of the technique is, however, relatively low. Deletions down to a size of 10–12 Mbp have been detected by the use of fixed diagnostic thresholds. In this study, we applied standard reference intervals as detection criteria on a number of deletions in the range of 3 Mbp to 14–18 Mbp. All deletions were detected. Thus, detection by standard reference intervals confers a considerably higher sensitivity to CGH analysis compared to fixed diagnostic thresholds. Genes Chromosomes Cancer 25:410–413, 1999. 1999 Wiley-Liss, Inc.
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DOI：
10.1002/(SICI)1098-2264(199908)25:43.0.CO;2-J
被引量：
年份：
1999
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