Low density lipoprotein undergoes oxidative modification in vivo
摘要：
It has been proposed that low density lipoprotein (LDL) must undergo oxidative modification before it can give rise to foam cells, the key component of the fatty streak lesion of atherosclerosis. Oxidation of LDL probably generates a broad spectrum of conjugates between fragments of oxidized fatty acids and apolipoprotein B. We now present three mutually supportive lines of evidence for oxidation of LDL in vivo: (i) Antibodies against oxidized LDL, malondialdehyde-lysine, or 4-hydroxynonenal-lysine recognize materials in the atherosclerotic lesions of LDL receptor-deficient rabbits; (ii) LDL gently extracted from lesions of these rabbits is recognized by an antiserum against malondialdehyde-conjugated LDL; (iii) autoantibodies against malondialdehyde-LDL (titers from 512 to >4096) can be demonstrated in rabbit and human sera.
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关键词：
Medical Sciences Atherosclerosis Autoantibodies to Oxidized Low Density Lipoprotein Malondialdehyde 4-hydroxynonenal
DOI：
10.1073/pnas.86.4.1372
被引量：
年份：
1989
Taylor & Francis
BMJ
doi.org
掌桥科研
万方医学
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