DNA Deaminating Ability and Genotoxicity of Nitric Oxide and Its Progenitors
摘要：
Nitric oxide (NO), a multifaceted bioregulatory agent and an environmental pollutant, can also cause genomic alterations. In vitro, NO deaminated deoxynucleosides, deoxynucleotides, and intact DNA at physiological pH. That similar DNA damage can also occur in vivo was tested by treating Salmonella typhimurium strain TA1535 with three NO-releasing compounds, including nitroglycerin. All proved mutagenic. Observed DNA sequence changes were greater than 99% C----T transitions in the hisG46 (CCC) target codon, consistent with a cytosine-deamination mechanism. Because exposure to endogenously and exogenously produced NO is extensive, this mechanism may contribute to the incidence of deamination-related genetic disease and cancer.
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关键词：
radiation, thermal, and other environ. pollutant effects on living orgs. and biol. mat nitric oxide mutagen screening disease incidence dna dna sequencing genetic effects salmonella typhimurium bacteria biological effects
DOI：
10.1126/science.1948068
被引量：
年份：
1991
Taylor & Francis
BMJ
Semantic Scholar
万方医学
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