Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity
摘要：
Activation of N-methyl-D-aspartate subtype glutamate receptors (NMDARs) is required for long-term potentiation (LTP) and long-term depression (LTD) of excitatory synaptic transmission at hippocampal CA1 synapses, the proposed cellular substrates of learning and memory. However, little is known about how activation of NMDARs leads to these two opposing forms of synaptic plasticity. Using hippocampal slice preparations, we showed that selectively blocking NMDARs that contain the NR2B subunit abolishes the induction of LTD but not LTP. In contrast, preferential inhibition of NR2A-containing NMDARs prevents the induction of LTP without affecting LTD production. These results demonstrate that distinct NMDAR subunits are critical factors that determine the polarity of synaptic plasticity.
展开
关键词：
Long-term depression Subunit composition Rat-brain Functional-properties Critical period Visual-cortex In-vitro Ltp Potentiation Dependence
DOI：
10.1126/science.1101128
被引量：
年份：
2004
掌桥科研
doi.org
Semantic Scholar
(全网免费下载)
万方医学
JSTOR
查看更多
BioMed Central
Europe PMC
(全网免费下载)
NCBI
Europe PMC
NCBI
Oxford Univ Press
JBC
dialnet.unirioja.es
adsabs.harvard.edu
ProQuest
ResearchGate
ResearchGate
(全网免费下载)
EBSCO
Citeseer
(全网免费下载)
jneurosci.org
cghjournal.org
mendeley.com
f1000.com
www.socolar.com
ajpcell.physiology.org
neurofuture.ru
(全网免费下载)
science.sciencemag.org
(全网免费下载)
rstb.royalsocietypublishing.org
jcb.rupress.org
msb.embopress.org
frontiersin.org
mysciencework.com
science-open.com
perspectivesmedicine.net
highbeam.com
eprints.ucl.ac.uk
readcube.com
hero.epa.gov
oarsijournal.com
scienceopen.com
wiki.brown.edu
(全网免费下载)
sciencemag.org
onAcademic
cshperspectives.cshlp.org
go.galegroup.com
molpharm.aspetjournals.org
sciencemag.org
(全网免费下载)
jacionline.org
sciencepubs.org
(全网免费下载)
stroke.ahajournals.org
Semantic Scholar
(全网免费下载)
Europe PMC
(全网免费下载)
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
science.sciencemag.org
(全网免费下载)
neurofuture.ru
(全网免费下载)
wiki.brown.edu
(全网免费下载)
sciencepubs.org
(全网免费下载)
sciencemag.org
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
