Mammary Fat Can Adjust Prolactin Effect on Mammary Epithelial Cells via Leptin and Estrogen
摘要：
Leptin, like estrogen, is one of the endo/paracrine factors, which are synthesized in and secreted from mature adipocytes. The roles of the mammary fat pad and mammary adipocytes in the initiation of lactation are not clear. In this study, we showed that combination of prolactin, leptin and estrogen elevated the expression of the milk protein beta-lactoglobulin. We also showed that after prolactin stimulate the secretion of leptin from the mammary fat, leptin upregulated the expression of estrogen receptor alpha in the mammary epithelial cells. Also, prolactin affected aromatase mRNA expression in the bovine mammary fat and we demonstrated that leptin and prolactin can affect cholesterol secretion from explants in culture to the medium. Therefore, we suggest that prolactin initiates estrogen expression (as represented by aromatase mRNA) in the mammary fat pad, whereas leptin stimulates estrogen receptor alpha expression in the mammary epithelial cells. We hypothesize that leptin and estrogen, secreted from the mammary fat regulate lactation after stimulation of prolactin.
展开
DOI：
10.1155/2009/427260
被引量：
年份：
2009
国家科技图书文献中心
(权威机构)
Semantic Scholar
(全网免费下载)
掌桥科研
dx.doi.org
Europe PMC
(全网免费下载)
查看更多
NCBI
(全网免费下载)
NCBI
Europe PMC
NCBI
Hindawi
(全网免费下载)
OALib
ResearchGate
(全网免费下载)
ResearchGate
EBSCO
EBSCO
Citeseer
(全网免费下载)
mendeley.com
biomedsearch.com
(全网免费下载)
mailer.oalib.net
deepdyve.com
pubfacts.com
scienceopen.com
onacademic.com
d.scholar.cnki.net
钛学术
学术范
(全网免费下载)
mysciencework.com
core.ac.uk
学术范
钛学术
(全网免费下载)
Semantic Scholar
(全网免费下载)
Hindawi
(全网免费下载)
Europe PMC
(全网免费下载)
NCBI
(全网免费下载)
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
学术范
(全网免费下载)
biomedsearch.com
(全网免费下载)
钛学术
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
