[Synthesis of CNS-activity of pyran derivatives: 6,8-dioxabicyclo(3,2,1)octane]
摘要：
The amino nitriles 4a,b and 5a,b, prepared from (1S,5R)-6,8-dioxabicyclo[3,2,1]octan-4-one (2), react with phenylmagnesium bromide to afford the diastereomeric 4-amino-4-phenyl derivatives 7a,b and 8a,b, respectively. The diastereomeric piperidine derivatives 7b and 8b show different CNS-activity.
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关键词：
Animals Mice Central Nervous System Bicyclo Compounds Piperidines Analgesics Anticonvulsants Aggression Stereoisomerism
DOI：
10.1002/ardp.19913240606
被引量：
年份：
1991
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