A sialosyl sulfonate as a potent inhibitor of influenza virus replication
摘要：
A new direction for influenza virus sialidase inhibitor development was identified using a sulfonate congener of 2-deoxy-2-β-H N-acetylneuraminic acid. Sialosyl sulfonates can be synthesised efficiently in four steps from N-acetylneuraminic acid via a microwave assisted decarboxylation. The presence of the sulfonate group significantly increases inhibition of influenza virus sialidase and viral infection when compared to the carboxylate congener, and also to the benchmark sialidase inhibitor 2,3-dehydro-2-deoxy-N-acetylneuraminic acid, Neu5Ac2en.
展开
DOI：
10.1039/C7OB00947J
年份：
2017
通过文献互助平台发起求助，成功后即可免费获取论文全文。
请先登入
相似文献
参考文献
引证文献
来源期刊
Organic & Biomolecular Chemistry
2017/06/27
站内活动
辅助模式
0
引用
文献可以批量引用啦~
欢迎点我试用！
