C-type lectin receptors and cytokines in fungal immunity

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摘要：

Fungi are the cause of opportunistic infections, predominantly in immunocompromised individuals although, primary fungal infections can occur in apparently healthy individuals. Successful host defence requires an effective innate and adaptive immune response. Central to host immune responses are the induction of cytokines; the signals which help to activate the innate immune system and which play a central role in directing the development of pathogen-specific immunity. C-type lectins play a central role in the recognition and shaping of immune responses to fungal pathogens, in part, through the induction and modulation of cytokine responses. Understanding which cytokines induce protective responses to these pathogens and how C-type lectins and other receptors direct cytokine production may allow development of novel antifungal therapies. Here we review the C-type lectins, their influence on cytokine production and subsequent immune responses in antifungal immunity.

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关键词：

AIRE, autoimmune regulator APCs, antigen presenting cells APECED, autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy BMDC, bone marrow-derived dendritic cells BMDM, bone marrow-derived macrophages CLRs, C-type lectin receptors CTLD, C-type lectin domain DC, dendritic cell DC-SIGN, DC-specific ICAM-3 grabbing non-integrin HIES, hyper IgE syndrome ITAM, immunoreceptor tyrosine-based activation-like motif Mincle, macrophage inducible C-type lectin MR, mannose recept