The 'ABC' of GABA receptors.
摘要：
In the conventional view, GABA acts at either ionotropic GABA A or metabotropic GABA B receptors. Recently, novel ionotropic GABA receptors that are composed of ρ-subunits have been identified in the vertebrate retina. These bicuculline- and baclofen-insensitive GABA receptors are frequently called GABA C, following an early suggestion by Graham Johnston and colleagues. An IUPHAR committee has recommended that the term GABA C be avoided and subclassifies the retinal receptors as GABA A0r. However, new evidence regarding the pharmacology, structure, function, genetics and cellular localization of ionotropic GABA receptors strengthens the case for the existence of two major classes of these receptors, GABA A and GABA C.
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关键词：
GABA C receptor GABA A receptor Chloride channel Ligand-gated channel Bicuculline CACA Receptor nomenclature
DOI：
10.1016/S0165-6147(99)01413-3
被引量：
年份：
2000
Elsevier
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