Formulations for nanoparticulate x-ray blood pool contrast agents using high molecular weight nonionic surfactants

阅读量:

39

申请(专利)号:

US07/991909

申请日期:

19921217

公开/公告号:

US05326552A

公开/公告日期:

19940705

申请(专利权)人:

STERLING WINTHROP INC.

发明人:

GC NaN Rajagopalan

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被引量:

266

摘要:

The present invention is directed to a composition comprised of nanoparticles containing an X-ray diagnostic compound, having a high molecular weight nonionic surfactant as a surface modifier adsorbed on the surface thereof and a cloud point modifier associated therewith.< P>The present invention is still further directed to a method for diagnostic imaging for use in medical procedures comprising administering to the body of a test subject in need of an X-ray an effective contrast producing amount of a composition comprised of nanoparticles containing an X-ray diagnostic compound, having a high molecular weight nonionic surfactant as a surface modifier adsorbed on the surface thereof and a cloud point modifier associated therewith.

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