The significance of MALT histology in thyroid lymphoma: A review of patients from the BNLI and royal marsden hospital

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作者：

R.W.，Laing，and，P.，Hoskin，and，B.，Vaughan，Hudson，and

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摘要：

Data from a series of 45 patients with Stage I and II non- Hodgkin's lymphoma (NHL) of the thyroid gland were analysed retrospectively to determine the incidence and prognostic significance of histopathological features of tumour origin from mucosa associated lymphoid tissue (MALT). The overall 5- and 10-year cause specific survival from NHL for the series was 79%. Evidence of tumour origin from MALT was the only significant prognostic factor for overall survival identified by multivariate analysis of the series (P <0.01). A total of 31 (69%) tumours showed such evidence, the cause specific patient survival from NHL at 5 and 10 years being 90% compared with only 55% at 5 years for the 14 patients without such evidence. For patients given initial treatment with radiotherapy alone, those with evidence of tumour origin from MALT had a relatively low relapse rate and a relatively high success rate from salvage therapy, compared with a relatively high relapse rate and negligible success from salvage therapy in those without evidence of such tumour origin.

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关键词：

MALT Non-Hodgkin's lymphoma Thyroid

DOI：

10.1016/S0936-6555(05)80271-7

被引量：

133

年份：

1994