Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I
摘要：
Human T cell lymphotropic virus I (HTLV-I) is the etiological agent for adult T cell leukemia and tropical spastic paraparesis (also termed HTLV-I-associated myelopathy). HTLV-I-infected peripheral blood T cells exhibit an initial phase of interleukin-2 (IL-2)-dependent growth; over time, by an unknown mechanism, the cells become IL-2-independent. Whereas the Jak kinases Jak1 and Jak3 and the signal transducer and activator of transcription proteins Stat3 and Stat5 are activated in normal T cells in response to IL-2, this signaling pathway was constitutively activated in HTLV-I-transformed cells. In HTLV-I-infected cord blood lymphocytes, the transition from IL-2-dependent to IL-2-independent growth correlated with the acquisition of a constitutively activated Jak-STAT pathway, which suggests that this pathway participates in HTLV-I-mediated T cell transformation.
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关键词：
Virus type i Receptor gamma chain Leukemia lymphoma Functional component Infected cells Il 2 receptor Proteins Leukocytes. Expression Growth
DOI：
10.1126/science.7604283
被引量：
年份：
1995
BMJ
掌桥科研
万方医学
Semantic Scholar
dx.doi.org
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