The Epstein-Barr Virus G-Protein-Coupled Receptor Contributes to Immune Evasion by Targeting MHC Class I Molecules for Degradation
摘要：
The DNase/alkaline exonuclease (AE) genes are well conserved in all herpesvirus families, but recent studies have shown that the AE proteins of gammaherpesviruses such as Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) exhibit an additional function which shuts down host protein synthesis. One correlate of this additional shutoff function is that levels of cell...
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关键词：
Humans Herpesvirus 4, Human CD8-Positive T-Lymphocytes Viral Proteins Receptors, G-Protein-Coupled Histocompatibility Antigens Class I Signal Transduction
DOI：
10.1371/journal.ppat.1000255
被引量：
年份：
2009
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