Therapeutic strategy targeting the mTOR–HIF-1–VEGF pathway in ovarian clear cell adenocarcinoma

来自 Wiley

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阅读量：

123

作者：

M Miyazawa，M Yasuda，M Fujita，H Kajiwara，K Hirabayashi，S Takekoshi，T Hirasawa，M Murakami，N Ogane，K Kiguchi

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摘要：

Malignant tumors usually involve a relatively hypoxic state, which induces overexpression of hypoxia-inducible factor-1α (HIF-1α) to satisfactorily enable the tumor to survive. Thus, inhibition of the mammalian target of rapamycin (mTOR) pathway including HIF-1α is expected to play a major role in suppression of tumor cell growth, having recently drawn much attention as an anti-cancer therapeutic strategy for various malignant tumors. In the present study, which compared clear cell adenocarcinoma (CLA) of the ovary with serous adenocarcinoma (SEA), the immunohistochemical expression of mTOR, phosphorylated-mTOR (p-mTOR), HIF-1α, and vascular endothelial growth factor (VEGF) was examined in surgically resected specimens of 29 SEA and 47 CLA. There were no significant differences in expression of mTOR, HIF-1α and VEGF between SEA and CLA, but it was noted that p-mTOR expression was more prominent in CLA than SEA. Then, using the cell lines of CLA (RMG-1 and

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关键词：

clear cell adenocarcinoma hypoxia-inducible factor-1&alpha ovary phosphorylated mammalian target of rapamycin rapamycin

DOI：

10.1111/j.1440-1827.2008.02320.x

被引量：

183

年份：

2009