Catalytic carbene insertion into C-H bonds.
摘要：
A study was conducted to investigate catalytic carbene insertion into C-H bonds. Investigations confirmed that C-C and C-H bond formation with the carbene occurred as the ligated metal dissociated at the same time without confirming to the same degree. Insertion into acrylic trans-substituted allylic C-H bonds gave high diastereocontrol despite relatively low diaestereoselectivity plaguing intermolecular C-H insertion with cyclic substrates. C-H insertion yields were higher due to less favorable competing cyclopropanation and the syn products forming with better enantiocontrol. It was also observed that the principal reaction competing with C-H insertion into allyl-OTBS was cyclopropanation.
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DOI：
10.1021/cr900239n
被引量：
年份：
2010
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