摘要：

Purpose; The purpose of this study is to clarify the relationship between the wearing of dentures and oral Candida species. Subjects; The subjects comprised 417 patients who visited the Kawasaki Dental and Oral Surgery Clinic during the 18 months from February 2007 to August 2008, exhibited no findings of oral candidiasis, and provided informed consent for the purpose of this study. Methods: All of the subjects were surveyed regarding their age, sex, and status of denture use, and as samples, we collected swabs from the dorsum of the tongue from all of the subjects, swabs from the mucosa below the denture base from 76 denture wearers (143 bases), and the ultrasonic cleaning fluid of the dentures of 25 patients (42 bases) who had worn dentures. The collected samples were seeded and cultured on CHROMAGAR CANDIDA; medium to detect and identify C. albicans, C. glabrata, C. tropicalis, C. parapsilosis, and C. krusei. Results; The detection rate of Candida species was significantly high among females, elderly patients, and denture wearers in the swabs from the dorsum of the tongue and among patients wearing maxillary dentures compared to those wearing mandibular dentures in the swabs from the mucosa below the denture base. When measured by the site of sample collection, the detection rate of Candida species from the ultrasonic cleaning fluid of the dentures exhibited significantly higher values compared to the swabs from the dorsum of the tongue and the mucosa below the denture base, and regarding the bacterial species, it was found that non-albicans Candida species such as C. glabrata were dominant Conclusion; The results of this study indicated a relationship between the wearing of dentures and oral Candida species and indicated that non-albicans Candida species were dominant in the samples of denture cleaning fluid.

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