Mutations of the E|[ndash]|cadherin gene in human gynecologic cancers
摘要：
Expression of the E-cadherin cell adhesion molecule is reduced in several types of human carcinomas, and the protein serves as an invasion suppressor in vitro. To determine if mutations of the E-cadherin gene (on chromosome 16q22) contribute to epithelial tumorigenesis, 135 carcinomas of the endometrium and ovary were examined for alterations in the E-cadherin coding region. Four mutations were identified: one somatic nonsense and one somatic missense mutation, both with retention of the wild-type alleles, and two missense mutations with somatic loss of heterozygosity in the tumour tissue. These data support the classification of E-cadherin as a human tumour suppressor gene.
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关键词：
GENETIC RISK ASSESSMENT PARALLELOGRAM APPROACH DNA-ADDUCT DOSIMETRY ETHYLENE OXIDE 1,3-BUTADIENE ACRYLAMIDE CYCLOPHOSPHAMIDE
DOI：
10.1038/ng0594-98
被引量：
年份：
1994
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