Generation and characterization of androgen receptor knockout (ARKO) mice: An in vivo model for the study of androgen functions in selective tissues
摘要：
By using a cre-lox conditional knockout strategy, we report here the generation of androgen receptor knockout (ARKO) mice. Phenotype analysis shows that ARKO male mice have a female-like appearance and body weight. Their testes are 80% smaller and serum testosterone concentrations are lower than in wild-type (wt) mice. Spermatogenesis is arrested at pachytene spermatocytes. The number and size of adipocytes are also different between the wt and ARKO mice. Cancellous bone volumes of ARKO male mice are reduced compared with wt littermates. In addition, we found the average number of pups per litter in homologous and heterozygous ARKO female mice is lower than in wt female mice, suggesting potential defects in female fertility and/or ovulation. The cre-lox ARKO mouse provides a much-needed in vivo animal model to study androgen functions in the selective androgen target tissues in female or male mice.
展开
关键词：
DOI：
10.1073/pnas.212474399
被引量：
年份：
2002
Semantic Scholar
(全网免费下载)
掌桥科研
万方医学
dx.doi.org
BioOne
查看更多
Europe PMC
(全网免费下载)
Europe PMC
NCBI
(全网免费下载)
NCBI
NCBI
Oxford Univ Press
JSTOR
AACR
JBC
adsabs.harvard.edu
ResearchGate
(全网免费下载)
EureKaMag.com
(全网免费下载)
ResearchGate
EBSCO
onAcademic
deepdyve.com
pubfacts.com
core.ac.uk
fasebj.org
press.endocrine.org
genemol.org
(全网免费下载)
urmc.rochester.edu
(全网免费下载)
pnas.org
(全网免费下载)
urmc.edu
(全网免费下载)
学术范
(全网免费下载)
diabetes.diabetesjournals.org
tmu.pure.elsevier.com
jme.endocrinology-journals.org
embomm.embopress.org
ajpendo.physiology.org
libir.tmu.edu.tw
(全网免费下载)
gastrojournal.org
bprcem.com
mendeley.com
fertstert.org
pubget.com
SAGE
学术范
urmc.rochester.edu
(全网免费下载)
biolreprod.org
jem.rupress.org
reproduction-online.org
mysciencework.com
scienceopen.com
mdanderson.influuent.utsystem.edu
science-open.com
pnas.org
The National Academy of Sciences of the United States of America
(全网免费下载)
Semantic Scholar
(全网免费下载)
Europe PMC
(全网免费下载)
NCBI
(全网免费下载)
ResearchGate
(全网免费下载)
EureKaMag.com
(全网免费下载)
urmc.rochester.edu
(全网免费下载)
pnas.org
(全网免费下载)
urmc.rochester.edu
(全网免费下载)
genemol.org
(全网免费下载)
urmc.edu
(全网免费下载)
libir.tmu.edu.tw
(全网免费下载)
学术范
(全网免费下载)
The National Academy of Sciences of the United States of America
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
