NMDA Receptors in Rat Cerebellum and Forebrain: Subtle Differences in Pharmacology and Modulation
摘要：
Binding of [<sup>3</sup>H]glutamate, [<sup>3</sup>H]glycine, and the glutamate antagonist [<sup>3</sup>H]CGS-19755 to NMDA-type glutamate receptors was examined in homogenates of rat forebrain and cerebellum. Most glutamate agonists had a higher affinity at the [<sup>3</sup>H]glutamate binding site of cerebellar NMDA receptors as compared with forebrain, whereas all the glutamate antagonists examined showed the reverse relationship. The [<sup>3</sup>H]glycine binding site of forebrain and cerebellar NMDA receptors showed a similar pharmacology in both brain regions. In the cerebellum, however, [<sup>3</sup>H]glycine bound to a second site with a 10-fold lower affinity and with a pharmacology that resembled that of the glycine/strychnine chloride channel. [<sup>3</sup>H]Glutamate binding was not affected by glycine agonists or antagonists, nor was [<sup>3</sup>H]glycine binding affected by glutamate agonists in either forebrain or cerebellum. Both CGS-19755 and 3-(2-carboxypip
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关键词：
NMDA receptors [<sup>3</sup>H]Glutamate binding [<sup>3</sup>H]CGS-19755 binding [<sup>3</sup>H]Glycine binding Cerebellum Forebrain
DOI：
10.1046/j.1471-4159.1995.64020651.x
被引量：
年份：
1995
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