Stereoselective synthesis of Jaspine B and its C2 epimer from Garner aldehyde
摘要：
Two different stereoselective routes for the synthesis of Jaspine B and its C2 epimer are presented here, starting from easily available Garner aldehyde. The key synthetic steps involved iodocyclization, organocuprate addition, HWE olefination, regioselective α-tosylation and cross metathesis reaction. This is the first report to synthesize Jaspine B involving iodocyclization.
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关键词：
D-LYXO-PHYTOSPHINGOSINE CYTOTOXIC ANHYDROPHYTOSPHINGOSINE ASYMMETRIC-SYNTHESIS BICYCLIC GUANIDINES CONJUGATE ADDITION MARINE SPONGE KEY STEP D-XYLOSE PACHASTRISSAMINE
DOI：
10.1039/c3ra41778f
被引量：
年份：
2013
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