The Direct Catalytic Asymmetric Aldol Reaction
摘要：
Asymmetric aldol reactions are a powerful method for the construction of carbon-carbon bonds in an enantioselective fashion. Historically this reaction has been performed in a stoichiometric fashion to control the various aspects of chemo-, diastereo-, regio- and enantioselectivity, however, a more atom economical approach would unite high selectivity with the use of only a catalytic amount of a chiral promoter. This critical review documents the development of direct catalytic asymmetric aldol methodologies, including organocatalytic and metal-based strategies. New methods have improved the reactivity, selectivity and substrate scope of the direct aldol reaction and enabled the synthesis of complex molecular targets (357 references).
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关键词：
Aldol reaction Asymmetric synthesis Bifunctional activators Chemical catalyst Enantioselective catalysis
DOI：
10.1039/b923537j
被引量：
年份：
2010
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