Broadly Protective Vaccine for Staphylococcus aureus Based on an in Vivo-Expressed Antigen
摘要：
Vaccines based on preferential expression of bacterial antigens during human infection have not been described. Staphylococcus aureus synthesized poly-N-succinyl β-1-6 glucosamine (PNSG) as a surface polysaccharide during human and animal infection, but few strains expressed PNSG in vitro. All S. aureus strains examined carried genes for PNSG synthesis. Immunization protected mice against kidney infections and death from strains that produced little PNSG in vitro. Nonimmune infected animals made antibody to PNSG, but serial in vitro cultures of kidney isolates yielded mostly cells that did not produce PNSG. PNSG is a candidate for use in a vaccine to protect against S. aureus infection.
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关键词：
Animals Rabbits Humans Mice Kidney Staphylococcus aureus Staphylococcal Infections Immunoglobulin G Immunization, Passive Vaccination
DOI：
10.1126/science.284.5419.1523
被引量：
年份：
1999
Taylor & Francis
Wiley
万方医学
dx.doi.org
NCBI
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