Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
摘要：
Alzheimer's tangles occur in anatomically connected regions. de Calignon et al. expressed tauP301L exclusively in mouse entorhinal cortex and found that with age, tangles occur both locally and in entorhinal projection targets, suggesting that tau may propagate across synapses.
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关键词：
Hippocampus Entorhinal Cortex Neurons Neurofibrillary Tangles Animals Mice, Inbred C57BL Mice, Transgenic Humans Mice Alzheimer Disease
DOI：
10.1016/j.neuron.2011.11.033
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年份：
2012
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