Abnormal Centrosome Amplification in the Absence of p53
摘要：
The centrosome plays a vital role in mitotic fidelity, ensuring establishment of bipolar spindles and balanced chromosome segregation. Centrosome duplication occurs only once during the cell cycle and is therefore highly regulated. Here, it is shown that in mouse embryonic fibroblasts (MEFs) lacking the p53 tumor suppressor protein, multiple copies of functionally competent centrosomes are generated during a single cell cycle. In contrast, MEFs prepared from normal mice or mice deficient in the retinoblastoma tumor suppressor gene product do not display these abnormalities. The abnormally amplified centrosomes profoundly affect mitotic fidelity, resulting in unequal segregation of chromosomes. These observations implicate p53 in the regulation of centrosome duplication and suggest one possible mechanism by which the loss of p53 may cause genetic instability.
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关键词：
Cells, Cultured Centrosome Mitotic Spindle Apparatus Fibroblasts Blood Animals Mice Culture Media Mitosis Interphase
DOI：
10.1126/science.271.5256.1744
被引量：
年份：
1996
BMJ
Semantic Scholar
dx.doi.org
JSTOR
NCBI
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