摘要：

Summary Objective Thyroid function and body mass are related, but the causal relationship remains unclear. Our objective was to investigate the longitudinal relationship between thyroid stimulating hormone (TSH) and body mass measures [body weight, body mass index (BMI), waist circumference (WC) and waist-hip-ratio (WHR)]. Design We used data from two waves of a population-based study: HUNT 2 (1995–1997) and 3 (2006–2008). Average follow-up time was 10·5years. Multivariable general linear and logistic regression models were used to assess the relation between TSH and the body mass measures. Participants In total 9954 women and 5066 men without self-reported thyroid disease and TSH within the reference range (0·5–3·5mU/l) at baseline and <10mU/l at follow-up. Results For each mU/l increase in TSH among women, weight increased 0·9kg (95% CI 0·8, 1·1), BMI 0·3kg/m 2 (95% CI 0·3, 0·4) and WC 0·6cm (95% CI 0·3, 0·8). In men, the corresponding figures were 0·8kg (95% CI 0·5, 1·0), 0·2kg/m 2 (95% CI 0·2, 0·3) and 0·5cm (95% CI 0·2, 0·8). In line with this, a weight gain of more than 5kg was associated with a TSH increase of 0·08mU/l (95% CI 0·06, 0·11) in women and 0·15mU/l (95% CI 0·12, 0·18) in men. Women who lost more than 5kg decreased their TSH by 0·12mU/l (95% CI 0·09, 0·16) and men by 0·03mU/l (95% CI 0.02, 0·09). Conclusion Weight gain is accompanied by increasing TSH, and weight loss in women is related to decreasing TSH.

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