Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria.
摘要：
Mitochondrial physiology is disrupted in either apoptosis or necrosis. Here, we report that a wide variety of apoptotic and necrotic stimuli induce progressive mitochondrial swelling and rupture. Discontinuity of the results in redistribution from the intermembrane space to the followed by subsequent depolarization. The mitochondrial Bcl-xL can inhibit these changes in treated with apoptotic stimuli. In addition, Bcl-xL-expressing adapt to withdrawal or treatment by maintaining a decreased potential. Bcl-xL expression also prevents mitochondrial swelling in response to agents that inhibit . These data suggest that Bcl-xL promotes survival by regulating the electrical and osmotic homeostasis of .
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关键词：
Cryptomeria japonica cell wall polysaccharides pectin rhamnogalacturonan I xylem differentiating zone
DOI：
10.1016/S0092-8674(00)80450-X
被引量：
年份：
1997
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