The insulin signaling system.

来自 NCBI

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阅读量：

131

作者：

MF White，CR Kahn

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摘要：

During the past few years, the insulin signalling system has emerged as a flexible network of interacting proteins. By utilizing the insulin receptor substrate (IRS)-proteins (IRS-1 and IRS-2), the insulin signal can be amplified or attenuated independently of insulin binding and tyrosine kinase activity, providing an extensible mechanism for signal transmission in multiple cellular backgrounds. By employing IRS-proteins to engage various signalling proteins, the insulin receptor avoids the stoichiometric constraints encountered by receptors which directly recruit SH2-proteins to their autophosphorylation sites. Finally, the shared use of IRS-proteins by multiple receptors is likely to reveal important connections between insulin and other hormones and cytokines which were previously unrecognized, or observed but unexplained. [Diabetologia (1997) 40: S 2–S 17]

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关键词：

Keywords Insulin action insulin signalling insulin receptor substrate proteins signal transduction

DOI：

10.1007/s001250051387

被引量：

3583

年份：

1994