Serological Demonstration of H–Y (Male) Antigen on Mouse Sperm

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作者：

ELLEN，H.，GOLDBERG，EDWARD，A.，BOYSE，DOROTHEA，BENNETT，MARGRIT，SCHEID

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摘要：

WE have recently overcome certain technical difficulties in applying the cytotoxicity test to mouse spermatozoa and have been able to show directly that H-2 antigens are expressed on these cells1, thus confirming less direct evidence leading to the same conclusion2. We have since applied the cytotoxicity test to sperm with antisera directed against a number of other systems of mouse alloantigens, TL3, θ4, Ly-A5 and Ly-B5, but none of these has given a positive reaction with sperm. This is not surprising because these are all "differentiation antigens"6 expressed primarily on lymphoid cells. Another antigenic system which distinguishes one mouse from another is H-Y. The H-Y antigen is carried by male cells only and is responsible for the rejection of male tissues by females of the same inbred strain7.

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关键词：

Laboratory Animals Laboratory Procedures Spermatozoa Autoimmune Response Clinical Research Research Methodology Laboratory Examinations and Diagnoses Examinations and Diagnoses Medical Procedures Medicine