Enantioselective construction of quaternary carbon centre catalysed by bifunctional organocatalyst
摘要：
The bifunctional thiourea–tertiary amine derivatives of simple chiral diamines serve as highly enantioselective catalysts for the Michael addition of α-substituted cyanoacetates to vinyl sulfones, giving an efficient protocol for the construction of an all-carbon substituted quaternary stereocentre.
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关键词：
ASYMMETRIC MICHAEL ADDITION BAYLIS-HILLMAN REACTION BETA-AMINO ACIDS DYNAMIC KINETIC RESOLUTION C BOND FORMATION MANNICH REACTIONS CONJUGATE ADDITION VINYL SULFONES THIOUREA ORGANOCATALYST STRECKER REACTION
DOI：
10.1039/b605871j
被引量：
年份：
2006
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