Protective effects of adenosine in myocardial ischemia [Review]
摘要：
Adenosine is released from the myocardium in response to a decrease in the oxygen supply/demand ratio, as is seen in myocardial ischemia; its protective role is manifested by coronary and collateral vessel vasodilation that increase oxygen supply and by multiple effects that act in concert to decrease myocardial oxygen demand (i.e., negative inotropism, chronotropism, and dromotropism). During periods of oxygen deprivation, adenosine enhances energy production via increased glycolytic flux and can act as a substrate for purine salvage to restore cellular energy charge during reperfusion. Adenosine limits the degree of vascular injury during ischemia and reperfusion by inhibition of oxygen radical release from activated neutrophils, thereby preventing endothelial cell damage, and by inhibition of platelet aggregation. These effects help to preserve endothelial cell function and microvascular perfusion. Long-term exposure to adenosine may also induce coronary angiogenesis.
展开
关键词：
REPERFUSION CARDIOPLEGIA ADENOSINE GLYCOLYSIS ENDOTHELIUM PLATELETS NEUTROPHILS RESEARCH ADVANCES SERIES ANGIOGENESIS MYOCARDIAL STUNNING
DOI：
10.1161/01.CIR.85.3.893
被引量：
年份：
1992
国家科技图书文献中心
(权威机构)
Wiley
Semantic Scholar
万方医学
万方医学
查看更多
Semantic Scholar
(全网免费下载)
dx.doi.org
NCBI
NCBI
Oxford Univ Press
Europe PMC
NRC Research Press
ResearchGate
ProQuest
EBSCO
circ.ahajournals.org
SAGE
ajconline.org
physreports.physiology.org
pubfacts.com
mendeley.com
science-open.com
jasn.asnjournals.org
journalofsurgicalresearch.com
fasebj.org
jacionline.org
jpet.aspetjournals.org
scienceopen.com
internationaljournalofcardiology.com
circ.ahajournals.org
(全网免费下载)
onAcademic
www.socolar.com
circ.ahajournals.org
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
