Chemotherapy-induced peripheral neuropathy (CIPN) and vitamin B12 deficiency
摘要：
Introduction Chemotherapy-induced peripheral neuropathy (CIPN) continues to be a major concern for oncological practise considering the increasing number of cancer survivors and the lack of standardised prevention or treatment [ 1 ]. The incidence of CIPN depends on the chemotherapy agent administered but is estimated to occur in one third of all patients undergoing chemotherapy [ 2 , 3 ]. The prevalence of CIPN has been estimated to be 68.1% the first month after the administration of neurotoxic chemotherapy agents and 60% 3months post chemotherapy treatment. Patients were found to still have 30% prevalence 6months or more after chemotherapy according to the results published in a systematic review conducted in 2014 [ 4 ]. Patients experiencing moderate to severe CIPN report a reduced quality of life [ 5 ], chronic discomfort [ 6 ] and disruption of physical abilities for general life activities which can be temporary or permanent [ 5 ]. Currently in clinical practise, CIPN is assessed using th ...
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关键词：
Chemotherapy Administration Princess Alexandra Hospital Raise Liver Enzyme Patient Neurotoxicity Questionnaire Intrinsic Factor Antibody
DOI：
10.1007/s00520-015-2725-6
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年份：
2015
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