Deficient Positive Selection of CD4 T Cells in Mice Displaying Altered Repertoires of MHC Class II–Bound Self-Peptides
摘要：
The role of self-peptides in positive selection of CD4+ T cells has been controversial. We show that some self-peptides are presented by the MHC class II molecule I-A(b) in mice lacking Ii or H-2M but not in mice expressing a transgene-encoded peptide fused to I-A(b). In experiments using specific antibodies to block selection, these low-abundance self-peptides were implicated in the positive selection of some CD4+ T cells in H-2M-/- mice. However, all three mutant backgrounds failed to positively select two class II-restricted transgenic T cell receptors. Our findings suggest that minor components of the self-peptide repertoire can contribute to positive selection of a significant number of CD4+ T cells. In addition, the data suggest that T cell receptor repertoires selected in wild-type mice and in mice displaying limited spectra of self-peptides are distinct.
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关键词：
Animals Mice, Inbred A Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Mice Epithelium CD4-Positive T-Lymphocytes Peptides Receptors, Antigen, T-Cell, alpha-beta
DOI：
10.1016/S1074-7613(00)80523-3
被引量：
年份：
1997
Elsevier
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