Enantioselective catalytic addition of nitroesters to N-carboalkyloxy imines: a route to quaternary stereocenters
摘要：
A readily available, low cost bifunctional organic catalyst promoted the addition of nitroesters to imines; in the reaction between 2-nitropropionates and -Boc protected aldehyde-imines the product bearing a new quaternary stereocenter was obtained in up to 81% ee. The positively charged catalyst was postulated to control the attack of the enolic form of nitroester to imine through a hydrogen bonding network.Graphical abstract
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DOI：
10.1016/j.tetlet.2009.05.036
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年份：
2009
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来源期刊
Tetrahedron Letters
2009
引用走势
2013
被引量：41
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