Advances in Giant Magnetoresistance Biosensors With Magnetic Nanoparticle Tags: Review and Outlook

来自 Semantic Scholar

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103

作者：

SX Wang，G Li

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摘要：

We present a review of giant magnetoresistance (GMR) spin valve sensors designed for detection of magnetic nanoparticles as biomolecular labels (nanotags) in magneto-nano biodetection technology. We discuss the intricacy of magneto-nano biosensor design and show that as few as approximately 14 monodisperse 16-nm superparamagnetic nanoparticles can be detected by submicron spin valve sensors at room temperature without resorting to lock-in (narrow band) detection. GMR biosensors and biochips have been successfully applied to the detection of biological events in the form of both protein and DNA assays with great speed, sensitivity, selectivity, and economy. The limit of molecular detection is well below 10 pM in concentration, and the protein or DNA assay time can be under two hours. The technology is highly scalable to deep multiplex detection of biomarkers in a complex disease, and amenable to integration of microfluidics and CMOS electronics for portable applications. On-chip CMOS circuitry makes a sensor density of 0.1-1 million sensors per square centimeter feasible and affordable. The theoretical and experimental results thus far suggest that magneto-nano biochip-based GMR sensor arrays and nanotags hold great promise in biomedicine, particularly for point-of-care molecular diagnostics of cancer, infectious diseases, radiation injury, cardiac diseases, and other diseases.

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关键词：

Bibliography, Theoretical or Mathematical, Experimental/ biomedical measurement biosensors cancer DNA lab-on-a-chip magnetic particles magnetoresistance molecular biophysics nanobiotechnology nanoparticles proteins tumours/ giant magnetoresistance biosensor magnetic nanoparticle magnetoresistance spin valve sensor biomolecular label detection magneto-nano biodetection magneto-nano biosensor superparamagnetic nanoparticle GMR biochips protein DNA molecular detection microfluidics CMOS electronics on-chip CMOS circuitry nanotags molecular diagnostics cancer infectious disease radiation injury cardiac disease size 16 nm temperature 293 K to 298 K/ A8780B Biosensors A8770 Biomedical engineering A8783 Nanotechnology applications in biomedicine A8715H Biomolecular dynamics, molecular probes, molecular pattern recognition B7230J Biosensors B7510 Biomedical measurement and imaging B7230M Microsensors and nanosensors/ size 1.6E-08 m temperature 2.93E+02 to 2.98E+02 K