The Antioxidant Activity of New Coumarin Derivatives
摘要：
The antioxidant activity of two synthesized coumarins namely,N-(4,7-dioxo-2- phenyl-1,3-oxazepin-3(2H,4H,7H)-yl)-2-(2-oxo-2H-chromen-4-yloxy)acetamide5andN-(4-oxo-2-phenylthiazolidin-3-yl)-2-(2-oxo-2H-chromen-4-yloxy)acetamide6were studied with the DPPH, hydrogen peroxide and nitric oxide radical methods and compared with the known antioxidant ascorbic acid. Compounds5and6were synthesized in a good yield from the addition reaction of maleic anhydride or mercaptoacetic acid to compound4,namelyN′-benzylidene-2-(2-oxo-2H-chromen-4-yloxy)acetohydrazide. Compound4was synthesized by the condensation of compound3, namely 2-(2-oxo-2H-chromen-4-yloxy) acetohydrazide, with benzaldehyde. Compound3,however, was synthesized from the addition of hydrazine to compound2,namely ethyl 2-(2-oxo-2H-chromen-4-yloxy)acetate, which was synthesized from the reaction of ethyl bromoacetate with 4-hydroxycoumarin1. Structures for the synthesized coumarins2–6are proposed on the basis of spectroscopic evidence.
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DOI：
10.3390/ijms12095747
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年份：
2011
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