Asymmetric Catalytic Mannich Reactions Catalyzed by Urea Derivatives:  Enantioselective Synthesis of β-Aryl-β-Amino Acids

阅读量:

90

作者:

AnnaG.WenzelEricN.Jacobsen

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摘要:

Highly enantioselective addition reactions between silyl ketene acetals and N-Boc aldimines are catalyzed by the thiourea-based catalyst 1c. Extraordinary scope is observed in this methodology with regard to the imine substrate, with aryl and heteroaromatic derivatives generally affording nearly quantitative yields of β-amino ester product in up to 98% enantioselectivity.

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DOI:

10.1021/ja028353g

被引量:

1263

年份:

2002

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