Cell Wall and Secreted Proteins ofCandida albicans: Identification, Function, and Expression

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阅读量：

117

作者：

WL Chaffin，JL Lopezribot，M Casanova，D Gozalbo，JP Martinez

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摘要：

The is essential to nearly every aspect of the biology and pathogenicity of . Although it was initially considered an almost inert cellular structure that protected the protoplast against osmotic offense, more recent studies have demonstrated that it is a dynamic organelle. The major components of the are and , which are associated with structural rigidity, and mannoproteins. The protein component, including both mannoprotein and nonmannoproteins, comprises some 40 or more moieties. Wall proteins may differ in their expression, , or topological location within the wall structure. Proteins may be modified by glycosylation (primarily addition of residues), , and ubiquitination. Among the secreted enzymes are those that are postulated to have substrates within the and those that find substrates in the environment. proteins have been implicated in to tissues and ligands. , complement fragments, and several components are among the proteins bound by proteins. Proteins related to the and families of conserved stress proteins and some glycolytic enzyme proteins are also found in the , apparently as bona fide components. In addition, the expression of some proteins is associated with the morphological growth form of the fungus and may play a role in . Finally, surface mannoproteins are strong immunogens that trigger and modulate the during .

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关键词：

Cell Wall Candida albicans Fungal Proteins

DOI：

10.1128/MMBR.62.1.130-180.1998

被引量：

1300

年份：

1998