Aliphatic amine polymer salts for tableting
申请(专利)号:
11/262291
申请日期:
10/27/2005
公开/公告号:
US7985418
公开/公告日期:
07/26/2011
申请(专利权)人:
Genzyme Corporation (Cambridge, MA, US)
被引量:
摘要:
The tablets, compositions and methods of the present invention, comprising a carbonate salt of an aliphatic amine polymer and s monovalent anion can prevent or ameliorate acidosis, in particular acidosis in patients with renal disease. The tablets and compositions of the present invention maintain a disintegration time of no greater than 30 minutes at 37° C. and at pH of at least 1 for a period of at least ten weeks at 60° C. Furthermore, the tablets are stable for extended periods of time without the need for specialized storage conditions.
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