Aliphatic amine polymer salts for tableting

阅读量:

36

申请(专利)号:

11/262291

申请日期:

10/27/2005

公开/公告号:

US7985418

公开/公告日期:

07/26/2011

申请(专利权)人:

Genzyme Corporation (Cambridge, MA, US)

发明人:

HR BhagatJM GoldbergAI HarianawalaL Brenner

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被引量:

15

摘要:

The tablets, compositions and methods of the present invention, comprising a carbonate salt of an aliphatic amine polymer and s monovalent anion can prevent or ameliorate acidosis, in particular acidosis in patients with renal disease. The tablets and compositions of the present invention maintain a disintegration time of no greater than 30 minutes at 37° C. and at pH of at least 1 for a period of at least ten weeks at 60° C. Furthermore, the tablets are stable for extended periods of time without the need for specialized storage conditions.

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2011
被引量:3

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