Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation
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摘要：
TheBcl6gene has been identified from the chromosomal translocation breakpoint in B cell lymphomas, and its products are expressed highly in germinal center (GC) B cells. To investigate the function of Bcl6 in lymphocytes, we have generated RAG1-deficient mice reconstituted with bone marrow cells from Bcl6-deficient mice (Bcl6/RM). Lymphogenesis in primary lymphoid tissues of Bcl6/RM is normal, and Bcl6/RM produced control levels of primary IgG1 antibodies specific to T cell–dependent antigens. However, GCs were not found in these mice. This defect was mainly due to the abnormalities of B cells. Therefore, Bcl6 is essential for the differentiation of GC B cells.
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DOI：
10.1084/jem.186.3.439
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年份：
1997
掌桥科研
万方医学
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