摘要：

OBJECTIVE To improve the total synthetic processing of Migrastatin.METHODS The target compound was synthesized from L-tartaric acid.After diisobutylaluminium hydride reduction,Pb(OAc)4 under the action of the rearrangement,LiBH4 reduction,4+2 Dies-Alder reaction,the Ferrier rearrangement under camphorsulfonic acid,hydrolysis,the key intermediate was generated.After the cyclization reaction of the key intermediate catalysed by Grubbs Ⅱ,the Migrastatin was produced.RESULTS and CONCLUSION Migrastatin was synthesized by an eleven-step reaction in total yield of 1.8%.

展开