Cutting Edge: Immune Cells as Sources and Targets of the IL-10 Family Members?

来自 NCBI

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116

作者：

K Wolk，S Kunz，K Asadullah，R Sabat

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摘要：

This study investigated the expression of five novel human IL-10-related molecules and their receptors in blood mononuclear cells. IL-19 and IL-20 were found to be preferentially expressed in monocytes. IL-22 and IL-26 (AK155) expression was exclusively detected in T cells, especially upon type 1 polarization, and in NK cells. IL-24 (melanoma differentiation-associated gene 7) expression was restricted to monocytes and T cells. Detection of these molecules in lymphocytes was predominantly linked to cellular activation. Regarding T cells, IL-26 was primarily produced by memory cells, and its expression was independent on costimulation. In contrast to the high expression of receptors for IL-10 homologs in different tissues and cell lines, monocytes and NK, B, and T cells showed clear expression only of IL-10R1, IL-10R2, and IL-20R2. In these cells, IL-20R2 might be part of a still-unknown receptor complex. Therefore, immune cells may represent a major source but a minor target of the novel IL-10 family members.

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关键词：

Leukocytes, Mononuclear Humans Growth Substances Receptors, Interleukin RNA, Messenger Interleukins Interleukin-10 Genes, Tumor Suppressor Receptors, Interleukin-10