Cholera and Prostaglandins

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CHOLERA exotoxin and prostaglandin E 1 have a similar effect on electrolytes in rabbit isolated ileal mucosa 1,2 . Application of either cholera exotoxin or prostaglandin E 1 (0.1 mM) to the mucosa inhibits sodium absorption and stimulates chloride secretion. Furthermore, prostaglandin infused into the superior mesenteric artery in dogs causes loss of fluid into the intestinE 1 . Greenough et al. 1 suggested that both the toxin and the prostaglandin E 1 act on cyclic adenosine monophosphate, because the responses are mimicked by the phosphodiesterase inhibitor theophylline. The similarity of effect of cholera exotoxin and prostaglandin E 1 extends to man. A characteristic of cholera is the profuse watery diarrhoea and cholera toxin and theophylline inhibit sodium absorption and stimulate chloride secretion in human isolated ileal mucosa. Prostaglandin E 1 given orally to man causes diarrhoea 3,4 which was described 4 as normally formed faeces in clear fluid which suggests an effect on intestinal secretion.

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关键词：

Humans Intestinal Mucosa Cholera Theophylline Prostaglandins Disease Outbreaks India Research Philosophy, Medical Toxins, Biological